
SCLC治疗正在“换道超车” | 2026ELCC前瞻


前言

春暖花开之际,2026年欧洲肺癌大会(ELCC)将于3月25日至28日在哥本哈根盛大召开。长期以来,小细胞肺癌
(SCLC)因其高侵袭性、易复发和预后差的特点,始终是肺癌医生面前一道难以逾越的“天堑”。然而,随着免疫治疗的不断深耕及新型疗法的异军突起,这一局面正在被改写。在今年的ELCC舞台上,多项突破性研究将为SCLC的临床诊疗带来怎样的“新风向”?医脉通为您抢先盘点SCLC领域看点。
摘要号:408O
英文标题:Phase II Study of iza-bren (BL-B01D1) in Combination with Serplulimab in Patients with Small Cell Lung Cancer (SCLC)
中文标题:iza-bren (BL-B01D1) 联合斯鲁利单抗
治疗SCLC的II期研究
摘要号:409O
英文标题:A phase I dose escalation trial of obrixtamig + ezabenlimab in patients (pts) with small cell lung cancer (SCLC) or other neuroendocrine carcinomas (NECs) expressing DLL3
中文标题:Obrixtamig联合Ezabenlimab治疗表达DLL3的SCLC或其他神经内分泌癌(NECs)患者的I期剂量递增试验
摘要号:410P
英文标题:Subsequent treatment (tx) patterns and impact on patient (pt) outcomes in the phase 3 ADRIATIC study of consolidation durvalumab (D) after concurrent chemoradiotherapy (cCRT) in limited-stage SCLC (LS-SCLC)
中文标题:III期ADRIATIC研究中局限期小细胞肺癌(LS-SCLC)患者同步放化疗(cCRT)后接受度伐利尤单抗
巩固治疗的后续治疗模式及其对患者预后的影响
摘要号:417P
英文标题:SNC115 in patients with relapsed/refractory small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC): Safety, pharmacokinetic, and preliminary efficacy results from a phase 1 study
中文标题: SNC115治疗复发/难治性SCLC和大细胞神经内分泌癌(LCNEC)患者:一项I期研究的安全性、药代动力学和初步疗效结果
摘要号:418P
英文标题:Adebrelimab plus chemotherapy (chemo) as first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC): 5-year update of the phase 3 CAPSTONE-1 study
中文标题:阿得贝利单抗
联合化疗一线治疗广泛期小细胞肺癌(ES-SCLC):III期CAPSTONE-1研究的5年更新数据
摘要号:426P
英文标题:Phase 2 Study of First-Line Pumitamig (PD-L1 _ VEGF-A bsAb) Plus Chemotherapy for Extensive-Stage Small-Cell Lung Cancer (ES-SCLC): Updated Efficacy and Safety Results
中文标题:Pumitamig(PD-L1/VEGF-A双抗)联合化疗一线治疗ES-SCLC的II期研究:更新的疗效和安全性结果
摘要号:427P
英文标题:Interim Results of a Randomized Phase II Trial of Trilaciclib Combined with Envafolimab, Etoposide, and Carboplatin as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer
摘要号:439TiP
英文标题:ROSETTA Lung-01: A Phase 3, Two-Stage Trial of Pumitamig, a PD-L1 _ VEGF-A Bispecific Antibody, Plus Chemotherapy Versus Atezolizumab + Chemotherapy as First-Line Treatment in Patients With Extensive-Stage Small Cell Lung Cancer
中文标题:ROSETTA Lung-01:一项比较Pumitamig(PD-L1/VEGF-A双特异性抗体)联合化疗与阿替利珠单抗
联合化疗一线治疗ES-SCLC的III期、两阶段试验
摘要号:440TiP
英文标题:A phase 2/3 trial of a PD-1/VEGF bispecific antibody (PF-08634404) in combination with chemotherapy in first-line for extensive-stage small cell lung cancer (Symbiotic-Lung-04)
中文标题:PD-1/VEGF双特异性抗体(PF-08634404)联合化疗一线治疗ES-SCLC的II/III期试验(Symbiotic-Lung-04)
摘要号:441TiP
英文标题:SEZanne: A phase 2 randomized, open-label, multicenter study to evaluate the optimal dose, safety, and efficacy of ABBV-706 in combination with atezolizumab (atezo) versus standard of care (SOC) in patients (pts) with previously untreated extensive-stage (ES) small cell lung cancer (SCLC)
中文标题:SEZanne:一项评估ABBV-706联合阿替利珠单抗对比标准治疗(SOC)在初治ES-SCLC患者中的最佳剂量、安全性和疗效的II期随机、开放标签、多中心研究
摘要号:442TiP
英文标题:DeLLphi-312 Phase 3 Trial-in-Progress: Tarlatamab With Durvalumab, Carboplatin and Etoposide versus Durvalumab, Carboplatin and Etoposide As First-Line (1L) Therapy in Extensive-Stage Small Cell Lung Cancer (ES-SCLC)
中文标题:DeLLphi-312 III期进行中试验(TiP):塔拉妥单抗(Tarlatamab)联合度伐利尤单抗、卡铂和依托泊苷对比度伐利尤单抗、卡铂和依托泊苷一线治疗ES-SCLC
摘要号:443TiP
英文标题:Maintenance therapy with adebrelimab plus vunakizumab for ES-SCLC after first-line induction with adebrelimab and chemotherapy: a prospective, single-arm, phase II clinical study
中文标题:阿得贝利单抗联合化疗一线诱导治疗后,采用阿得贝利单抗联合vunakizumab维持治疗ES-SCLC:一项前瞻性、单臂、II期临床研究
编辑:Faline
审校:Faline
排版:Faline
执行:Faline
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