ECTRIMS 2025 中国之声 | 50余项中国学者研究成果入选,引领神免领域新突破

来源:医脉通 2025.09.04
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当地时间2025年9月24-26日,第41届欧洲多发性硬化治疗与研究委员会大会(ECTRIMS 2025)将在西班牙巴塞罗那召开。ECTRIMS大会是全球多发性硬化领域规模巨大且极具影响力的会议,致力于多发性硬化的基础和临床研究与治疗。


日前,ECTRIMS官方在线公布了本届大会入选的摘要标题,中国研究团队再创新高,共有50余项研究成果成功入选。这些研究涵盖了视神经脊髓炎谱系疾病(NMOSD)、多发性硬化(MS)以及髓鞘少突胶质细胞糖蛋白抗体相关疾病 (MOGAD)等神经免疫领域的前沿探索与创新疗法,充分展现了中国科研团队在该领域的卓越贡献。以下为入选研究的简要介绍(排名不分先后,如有遗漏或任何问题,欢迎留言反馈~)




视神经脊髓炎谱系疾病(NMOSD)


O132

Type II Anti-CD20 Antibody MIL62 in AQP4-Positive Neuromyelitis Optica Spectrum Disorder: A Multicenter, Randomized, Double-Blind, Phase III Trial

II型抗CD20抗体MIL62在AQP4阳性NMOSD中的应用:一项多中心、随机、双盲、III期临床试验


作者:黄德晖(解放军总医院第一医学中心)



O135

Efficacy and Safety of Ofatumumab in the Treatment of NMOSD: A Multi-Center Prospective Study

奥法木单抗治疗NMOSD的疗效和安全性:一项多中心前瞻性研究


作者:杨欢(中南大学湘雅医院)

O051

Efficacy and Safety of Inebilizumab versus Rituximab in Optic Neuromyelitis Optica Spectrum Disorders: A Real-World,Multicentre Cohort Study

伊奈利珠单抗与利妥昔单抗治疗NMOSD的疗效和安全性:一项真实世界、多中心队列研究


作者:冯金洲(重庆医科大学附属第一医院)

O137

Efficacy and Safety of Inebilizumab in the Treatment of Recurrent Neuromyelitis Optica Spectrum Disorder: A Multicenter, Randomized, Controlled, Open-Label Study

伊奈利珠单抗治疗复发性NMOSD的疗效和安全性:一项多中心、随机、对照、开放标签研究


作者:郭守刚(山东省立医院)

P862

Satralizumab treatment in Chinese patients With AQP4-ab-positive Neuromyelitis Optica Specturm Disorder: A prospective study

萨特利珠单抗治疗中国 AQP4抗体阳性NMOSD患者:一项前瞻性研究


作者:黄文娟(复旦大学附属华山医院)


P859

Multicenter Real-World Study of Inebilizumab in Patients with Neuromyelitis Optica Spectrum Disorder

伊奈利珠单抗治疗NMOSD患者的多中心真实世界研究


作者:桂梦翠(华中科技大学同济医学院附属同济医院)

P858

Ofatumumab Treatment in Patients with Neuromyelitis Optica Spectrum Disorder

奥法木单抗治疗NMOSD患者


作者:张超(天津医科大学总医院)

P843

Inebilizumab treatment in Chinese Adult patients With AQP4-ab-positive Neuromyelitis Optica Specturm Disorder: A prospective study

伊奈利珠单抗治疗中国成年 AQP4抗体阳性NMOSD患者的前瞻性研究


作者:黄文娟(复旦大学附属华山医院)

P726

Progressive Retinal and Microvascular Neurodegeneration in Neuromyelitis Optica Spectrum Disorders: A Longitudinal SS-OCT/OCTA Study

NMOSD中的进行性视网膜和微血管神经退行性变:一项纵向 SS-OCT/OCTA 研究


作者:孔令瑶(四川大学华西医院)

P690

Acute spinal MRI markers for early differentiation of neuromyelitis optica spectrum disorder from idiopathic transverse myelitis: a cohort study at first ATM onset

急性脊髓 MRI 标记物用于早期鉴别NMOSD与特发性横贯性脊髓炎:首次 ATM 发病时的队列研究


作者:Ying Zhang(成都)

P355

Long-term safety and effectiveness of B-cell depletion therapy in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: A real-world multicentre cohort study from northern China

B细胞耗竭疗法治疗AQP4抗体阳性NMOAS患者的长期安全性和有效性:一项来自中国北方的真实世界多中心队列研究


作者:汪春娟(山东省立医院)

P1838

Preliminary Experience of Inebilizumab in Treating Neuromyelitis Optica Spectrum Disorder Comorbid with Primary Sjögren's Syndrome: A Single-Center Prospective Real-World Study

伊奈利珠单抗治疗NMOSD合并原发性干燥综合征的初步经验:一项单中心前瞻性真实世界研究


作者:Chao Yuan(广州)

P1813

Evaluation of the Efficacy and Safety of Sattralizumab in a Pregnant NMOSD Patient with AQP4/MOG-IgG Dual Seropositive: A Case Report

萨特利珠单抗治疗AQP4/MOG-IgG 双阳性 妊娠期NMOSD患者的疗效和安全性评估:一例病例报告


作者:罗叶婷(赣州市人民医院)

P1792

Inebilizumab in the Management of Overlapping NMOSD and Anti-NMDAR Encephalitis: A Case Report

伊奈利珠单抗治疗NMOSD合并抗NMDAR脑炎1例


作者:Yue Huang(郑州)

P1755

Adherence, Safety, and Efficacy of Inebilizumab in Chinese Patients with Neuromyelitis Optica Spectrum Disorder (NMOSD): A Multicenter Retrospective Study

伊奈利珠单抗对中国NMOSD患者的依从性、安全性和有效性:一项多中心回顾性研究


作者:杨欢(中南大学湘雅医院)

P1746

Eculizumab for the acute attack of neuromyelitis optica spectrum disorder

依库珠单抗治疗NMOSD急性发作


作者:谭红梅(复旦大学附属华山医院)

P1700

Lymphoplasmapheresis for steroid-refractory neuromyelitis optica spectrum disorder: A multicenter study in China

淋巴细胞血浆置换治疗激素耐药性NMOSD:中国多中心研究


作者:杨欢(中南大学湘雅医院)

P1633

Zanubrutinib for Treatment of Patients with Recurrent Neuromyelitis Optica Spectrum Disorders

泽布替尼用于治疗复发性NMOSD患者


作者:刘峥(首都医科大学宣武医院)

P1419

Glymphatic dysfunction in neuromyelitis optica spectrum disorder: association with disability and brain atrophy

NMOSD中的淋巴功能障碍:与残疾和脑萎缩的关系


作者:Ying Zhang(成都)

P141

CXCL9 is an important chemokine in the modeling of neuromyelitis optica spectrum disorder in mice using adoptive transferred Tfh and Th17 cells

CXCL9 是采用过继转移 Tfh 和 Th17 细胞构建小鼠NMOSD模型中的一种重要趋化因子


作者:汪亮(复旦大学附属华山医院 ) 

P1074

Satralizumab in Chinese Patients with NMOSD: Interim analysis from Real-World Data in the SAILOR Study

萨特利珠单抗治疗中国 NMOSD 患者:SAILOR 研究真实世界数据的中期分析


作者:樊茉丽(天津医科大学总医院)

P1073

Predictors of treatment failure in a cohort with neuromyelitis optica spectrum disorder use immunosuppressants

NMOSD患者使用免疫抑制剂治疗失败的预测因素


作者:王锐(四川大学华西医院)

P1071

The effect of Inalizumab treatment on pulmonary nodules in patients with neuromyelitis optica spectrum disorder

伊奈利珠单抗治疗对NMOSD患者肺结节的影响


作者:Qiqi Yin(昆明)


P1048

Chinese Delphi Consensus for the Multidisciplinary Management of NMOSD

中国NMOSD多学科管理德尔菲共识


作者:尹翮翔(北京协和医院 )



多发性硬化(MS)


P304

Reconstitution of CXCR3+ CCR6+ Th17.1-like T cells in response to ofatumumab therapy in patients with multiple sclerosis

MS患者接受奥法木单抗治疗后 CXCR3+ CCR6+ Th17.1 样 T 细胞的重建


作者:张超(天津医科大学总医院)



P1553

Unraveling the associations between brain metabolic biomarkers and disease disablity in multiple sclerosis

揭示大脑代谢生物标志物与MS疾病致残之间的关联


作者:陈向军(复旦大学附属华山医院)

P1575

Serum, CSF and MRI biomarkers predict contrast enhancement with gadolinium in multiple sclerosis

血清、脑脊液和 MRI 生物标志物可预测MS患者钆造影增强效果


作者:陈向军(复旦大学附属华山医院)

P148

Aberrant erythropoiesis leads to inflammatory anemia in multiple sclerosis

MS中红细胞生成异常导致炎症性贫血


作者:Wenyan He(北京)

P646

Erythrocyte-Mediated MOG Protein Transport and Immune Regulation in Multiple Sclerosis: Insights from EAE Models

红细胞介导的 MOG 蛋白转运和免疫调节在MS中的作用:基于EAE 模型的启示


作者:Yang Lingfei(郑州)

P093 

Erythrocyte-Mediated Myelin Oligodendrocyte Glycoprotein Trafficking in Multiple Sclerosis: A Multicenter Biomarker Study

确定MS和认知表现之间的共同和因果遗传关联


作者:Xiaofei Wang (成都)

P093

Neutrophil Extracellular Traps-Mediated Meningeal Inflammation Promotes Demyelination in Multiple Sclerosis

MS中红细胞介导的髓鞘少突胶质细胞糖蛋白运输:一项多中心生物标志物研究


作者:Hao Qianmeng(郑州)

P1317

Do progression in  multiple sclerosis share neurodegenerative mechanisms with other neurodegenerative diseases

MS的进展是否与其他神经退行性疾病具有共同的神经退行性机制


作者:Yangyang Zhang (成都)

P1616

Identifying causal genes for multiple sclerosis and neuromyelitis optica via integrating multi-omics

通过整合多组学识别MS和视神经脊髓炎的致病基因


作者:汪亮(复旦大学附属华山医院)

P1298

Sleep quality and insomnia in people with multiple sclerosis

MS患者的睡眠质量和失眠


作者:张遥(北京协和医院)

O114

Risk factors for serious infection in patients with multiple sclerosis treated with Ocrelizumab —— a real-world multi-centre prospective cohort study

奥瑞利珠单抗治疗MS患者严重感染的危险因素——一项真实世界多中心前瞻性队列研究


作者:张遥(北京协和医院)

P1775

Effectiveness and safety of ofatumumab in treatment-naive and oral DMT-switched multiple sclerosis patients: a multicenter observational study in China

奥法木单抗对初治和口服DMT转换的MS患者中的有效性和安全性:一项中国多中心观察性研究


作者:冯金洲(重庆医科大学附属第一医院)

P1328

Genetic Architecture of Progressive Multiple Sclerosis: Causal Relationships with Comorbidities and Identification of Potential Therapeutic Targets

进行性MS的遗传结构:与合并症的因果关系及潜在治疗靶点的识别


作者:王晓斐(四川大学华西医院)

O152

Anti-BCMA CAR T cell therapy in patients with Multiple Sclerosis

抗BCMA CAR T细胞疗法在MS患者中的应用


作者:秦川(华中科技大学同济医学院附属同济医院)

P1953

Clonally Expanded Cytotoxic CD8+TEFF-ITGB1 Cells with Enhanced CNS Migration Drive Disease Progression in Multiple Sclerosis

克隆扩增的细胞毒性CD8+TEFF-ITGB1细胞通过增强中枢神经系统迁移驱动MS的疾病进展


作者:石紫燕(四川大学华西医院)

P1568

Investigate potential metabolomic biomarkers for Epstein-Barr Virus (EBV) positive Relapse Remitting Multiple Sclerosis

探究EB病毒阳性复发缓解型MS的潜在代谢组学生物标志物


作者:pei shang(广州)

P416

Short-term Change of Paramagnetic Rim Lesion and its Association with Clinical Outcome in Multiple Sclerosis: A Retrospective, Longitudinal Study

MS中顺磁性边缘病变的短期变化及其与临床结局的关联:一项回顾性纵向研究


作者:fanru he(上海)



髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)


P027

Parameters predicting MOGAD relapse risk at the first attack: a cohort study in China

首次发作时预测MOGAD复发风险的参数:一项中国队列研究


作者:Xixi Yang(北京)



P1091

Headache in myelin oligodendrocyte glycoprotein antibody-associated disease

MOGAD引起的头痛


作者:Mengyao Zhang(北京)

P1039

Co-occurrence of EBV Infection and MOGAD: A Series of Case Reports

EBV 感染与 MOGAD 同时发生:一系列病例报告


作者:蒋薇(天津医科大学总医院)

P1053

Cell Type-Specific Immune Regulation in MOG Antibody-Associated Disease Revealed by Single-cell RNA Sequencing

单细胞 RNA 测序揭示 MOG 抗体相关疾病中的细胞类型特异性免疫调节


作者:张包静子(复旦大学附属华山医院)

P515

Elevated Serum Complement Levels are Correlated with Disease Activity and Predict Relapse in Myelin Oligodendrocyte Glycoprotein Antibody-Related Disease

血清补体水平升高与疾病活动性相关,并可预测MOGAD的复发


作者:钟晓南(中山大学附属第三医院)

P1753

Real-world Evaluation of the Efficacy and Safety of Ofatumumab as a Second-line Therapy in Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease

奥法木单抗作为MOGAD二线治疗的疗效和安全性的真实世界评估


作者:范宇欣(复旦大学附属华山医院)

P016

Evaluation of the diagnostic value of two cell-based assays for MOG-IgG-associated diseases: a paired design observational study

评估两种基于细胞的检测方法对MOGAD的诊断价值:一项配对设计观察性研究


作者:王舟舟(复旦大学附属华山医院)




GFAP-A等其他


P1016

Glial Fibrillary Acidic Protein Astrocytopathy: Clinical Presentations, MRI Features, and Treatment Responsiveness based Based on a Two-center Chinese Cohort Study

GFAP-A:基于中国双中心队列研究的临床表现、MRI 特征和治疗反应


作者:施福东(首都医科大学附属北京天坛医院/天津医科大学总医院)



P305

NEK2 Regulates B Cell Function and the Severity of Autoimmune Encephalomyelitis

NEK2调控B细胞功能和自身免疫性脑脊髓炎的严重程度


作者:张超(天津医科大学总医院)

P1040

Consistent Detection of AQP4 Antibodies: A Comparative Analysis Between Fixed and Live Cell-Based Assays

AQP4 抗体一致性检测:固定细胞和活细胞检测方法的比较分析


作者:冯金洲(重庆医科大学附属第一医院)

P1512

Clinical Value of 18F-FDG-PET in Brain Nucleus Accumbens Network in Anti-LGI1 Encephalitis

18F-FDG-PET显像在抗LGI1脑炎中伏隔核网络的临床价值


作者:徐望舒(首都医科大学附属北京天坛医院)

P162

Arresting brain inflammation and degeneration by antagonizing formyl peptide receptor 1

通过拮抗甲酰肽受体1抑制脑部炎症与神经退行性变


作者:Shuzhen Guan(天津)